SpheraCosmolife is a unique application for cosmetic ingredients risk assessment, covering both exposure and hazard.
The focus is on systemic toxicity and the Margin of Safety (MoS) is calculated, considering the No Observed Adverse Effect Level (NOAEL). It also includes the Threshold of Toxicological Concern (TTC) approach (Williams et al., 2016), and a number of tools for mutagenicity, genotoxicity and skin sensitization for a comprehensive assessment. Additional endpoints will be added in the future.
The software can process multiple ingredients in a product, and make predictions, in case of missing experimental values. The user provides information regarding the ingredients, their concentration and the product type, while the software checks if the ingredient is present in the Annexes of the “Regulation (EC) No. 1223/2009 of the European parliament and of the Council of 30 November 2009 on cosmetic products”. Then, the software searches for values present in its database useful for TTC, genotoxicity and skin sensitization. Moreover, the software allows comparing the external and internal exposure, using a specific model for skin permeation.
SpheraCosmolife has been developed inside the LIFE VERMEER project (LIFE16 ENV/IT/000167) by Kode Chemoinformatics together with the other partners. It is distributed under an open source license and it is freely downloadable from the VEGA HUB website.